One-year experience in patients treated with auranofin following completion of a parallel, controlled trial comparing auranofin, gold sodium thiomalate, and placebo
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چکیده
منابع مشابه
Gold levels produced by treatment with auranofin and sodium aurothiomalate.
Sixty-three patients with rheumatoid arthritis were randomly divided into 3 groups, and treated with either sodium aurothiomalate (Myocrisin), auranofin, or placebo. Gold levels in whole blood, plasma, and haemolysate were measured serially along with clinical and laboratory parameters of efficacy. Auranofin produced a higher ratio of haemolysate to plasma gold than Myocrisin, and it appears th...
متن کاملLatent human leukocyte collagenase can be activated by gold thioglucose and gold sodium thiomalate, but not by auranofin.
Gold thioglucose and gold sodium thiomalate were shown to be potent activators of latent human leukocyte collagenase. No activation by auranofin was noted. The activation may proceed through the action of gold on the essential sulfhydryl groups of latent enzyme and, thereby, mimick the action of the known organomercurial activators.
متن کاملA Controlled Clinical Trial
A prospective controlled, double-Wind multicenter trial compared placebo, auranofin (an orally administered gold camplex), and parenteral gold sodium thiomalate (GST) in patients with active rheumatoid arthritis (RA). Of 193 patients who received any treatment, the only important improvement identified for either auranofin or GST was for paidtenderness scores. When 161 patients who completed 20...
متن کاملA double-blind placebo-controlled study of auranofin in patients with psoriatic arthritis.
Two hundred thirty-eight patients with psoriatic arthritis were entered into a 6-month, multicenter, double-blind trial comparing auranofin and placebo. Polyarthritis (greater than 5 tender joints) was present in 90% of the patients, and 94% were seronegative. Auranofin treatment was statistically superior to placebo treatment, according to physician's global assessment and functional scores. A...
متن کاملEnhanced eryptosis following auranofin exposure.
BACKGROUND/AIMS The antiinflammatory, antimicrobial and anticancer drug auranofin has previously been shown to trigger apoptosis, the suicidal death of nucleated cells. Side effects of the drug include anaemia. At least in theory the anaemia could result from stimulation of suicidal death of erythrocytes or eryptosis, which involves cell shrinkage and cell membrane scrambling with phosphatidyls...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1988
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780310102